Publications

Publications since 2012

2019

– Type 1 Diabetes Mellitus reversal via implantation of magnetically purified microencapsulated pseudoislets. Int J Pharm. Espona-Noguera, A.; Etxebarria-Elezgarai, J.; Saenz del Burgo, L.; Canibano-Hernandez, A.; Gurruchaga, H.; Blanco, F. J.; Orive, G.; Hernandez, Rosa M.; Benito-Lopez, F.; Ciriza, J.; Basabe-Desmonts, L.; Pedraz, J.L. 2019; 560:65-77. DOI: 10.1016/j.ijpharm.2019.01.058.

 

– Platelet-rich plasma in osteoarthritis treatment: review of current evidence. Ther Adv Chronic Dis. Gato-Calvo, L; Magalhaes, J; Ruiz-Romero, C; Blanco, FJ.; Burguera, EF.  2019. DOI: 10.1177/2040622319825567.

 

– 2018 update of the EULAR recommendations for the management of hand osteoarthritis Ann Rheum Dis. Kloppenburg M, Kroon FP, Blanco FJ, Doherty M, Dziedzic KS, Greibrokk E, Haugen IK, Herrero-Beaumont G, Jonsson H, Kjeken I, Maheu E, Ramonda R, Ritt MJ, Smeets W, Smolen JS, Stamm TA, Szekanecz Z, Wittoek R, Carmona L..  2019. 78 (1):16-24. DOI: 10.1136/annrheumdis-2018-213826.

 

– Src and podoplanin forge a path to destruction. Drug Discov Today. Krishnan, Harini; Miller, W. Todd; Blanco, Francisco J.; Goldberg, Gary S. 2019; 24 (1): 241-249. DOI: 10.1016/j.drudis.2018.07.009.

 

– Leukocyte Telomere Length in Patients with Radiographic Knee Osteoarthritis Environ Mol Mutagen. Mosquera, A; Rego-Perez, I; Blanco, FJ.; Fernandez, JL.  2019; 60(3): 298-301. DOI: 10.1002/em.22247.

 

– Wnt and RUNX2 mediate cartilage breakdown by osteoarthritis synovial fibroblast-derived ADAMTS-7 and -12. J Cell Mol Med. Pérez-García S, Carrión M, Villanueva-Romero R, Hermida-Gómez T, Fernández-Moreno M, Mellado M, Blanco FJ, Juarranz Y, Gomariz RP. 2019 Mar 22. doi: 10.1111/jcmm.14283. [Epub ahead of print]

 

– Prevalence of rheumatic diseases in adult population in Spain (EPISER 2016 study): Aims and methodology. Reumatol Clin. Seoane-Mato D, Sánchez-Piedra C, Silva-Fernández L, Sivera F, Blanco FJ, Pérez Ruiz F, Juan-Mas A, Pego-Reigosa JM, Narváez J, Quilis Martí N, Cortés Verdú R, Antón-Pagés F, Quevedo Vila V, Garrido Courel L, Del Amo NDV, Paniagua Zudaire I, Añez Sturchio G, Medina Varo F, Ruiz Tudela MDM, Romero Pérez A, Ballina J, Brandy García A, Fábregas Canales D, Font Gayá T, Bordoy Ferrer C, González Álvarez B, Casas Hernández L, Álvarez Reyes F, Delgado Sánchez M, Martínez Dubois C, Sánchez-Fernández SÁ, Rojas Vargas LM, García Morales PV, Olivé A, Rubio Muñoz P, Larrosa M, Navarro Ricos N, Graell Martín E, Chamizo E, Chaves Chaparro L, Rojas Herrera S, Pons Dolset J, Polo Ostariz MÁ, Ruiz-Alejos Garrido S, Macía Villa C, Cruz Valenciano A, González Gómez ML, Morcillo Valle M, Palma Sánchez D, Moreno Martínez MJ, Mayor González M, Atxotegi Sáenz de Buruaga J, Urionagüena Onaindia I, Blanco Cáceres BA, Díaz-González F, Bustabad S. 2019; 15 (2): 90-96. DOI: 10.1016/j.reuma.2017.06.009.

 

– Mitochondrial DNA haplogroups influence the risk of aortic stenosis. Asian Cardiovasc Thorac Ann. Serrano-Teruel ME, Garcia-Vieites M, Rego-Perez I, Domenech-Garcia N, Blanco-Garcia F, Cuenca-Castillo JJ, Bautista-Hernandez V 2019; 27 (1): 5-10. DOI: 10.1177/0218492318813220.

 

2018

– Clinical, Patient-Reported, and Ultrasound Outcomes from an Open-Label, 12-week Observational Study of Certolizumab Pegol in Spanish Patients with Rheumatoid Arthritis with or without Prior Anti-TNF Exposure. Reumatol Clin. Blanco FJ, Rubio-Romero E, Sanmartí R, Díaz-Torné C, Talavera P, Dunkel J, Naredo E; SONAR Study Team. 2018. DOI: 10.1016/j.reuma.2018.07.009.

 

– Osteoarthritis and atherosclerosis in joint disease. Reumatol Clin. Blanco FJ. 2018; 14 (5): 251-253. DOI: 10.1016/j.reuma.2018.08.001.

 

– Induced pluripotent stem cells for cartilage repair: current status and future perspectives. Eur Cell Mater. Castro-Vinuelas, R; Sanjurjo-Rodriguez, C; Pineiro-Ramil, M; Hermida-Gomez, T; Fuentes-Boquete, IM; de Toro-Santos, FJ; Blanco-Garcia, FJ; Diaz-Prado, SM. 2018; 36: 96-109. DOI: 10.22203/eCM.v036a08.

 

– Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations. Genome Med. Marquez, A; Kerick, M; Zhernakova, A; Gutierrez-Achury, J; Chen, WM; Onengut-Gumuscu, S; Gonzalez-Alvaro, I; Rodriguez-Rodriguez, L; Rios-Fernandez, R; Gonzalez-Gay, MA; Mayes, MD.; Raychaudhuri, S; Rich, SS; Wijmenga, C; Martin, J. Coeliac Dis Immunochip Consortium; Rheumatoid Arthrit Consortium Int; Int Scleroderma Grp; Type 1 Diabet Genetics Consortium 2018 Dec 20;10(1):97. doi: 10.1186/s13073-018-0604-8.

 

– Incident hand OA is strongly associated with reduced peripheral blood leukocyte telomere length. Osteoarthritis Cartilage. McAlindon, T.; Roberts, M.; Driban, J.; Schaefer, L.; Haugen, I. K.; Smith, S. E.; Duryea, J.; Cunha, D.; Blanco, F.; Fernandez-Garcia, J. -L.; Eaton, C.  2018; 26 (12): 1651-1657. DOI: 10.1016/j.joca.2018.08.010.

 

– Early and sustained efficacy with apremilast monotherapy in biological-naive patients with psoriatic arthritis: a phase IIIB, randomised controlled trial (ACTIVE). Ann Rheum Dis. Nash P, Ohson K, Walsh J, Delev N, Nguyen D, Teng L, Gómez-Reino JJ, Aelion J. ACTIVE Investigators. 2018; 77 (5): 690-698. DOI: 10.1136/annrheumdis-2017-211568.

 

– Efficacy of tocilizumab monotherapy after response to combined tocilizumab and methotrexate in patients with rheumatoid arthritis: the randomised JUST-ACT study. Clin Exp Rheumatol. Pablos JL, Navarro F, Blanco FJ, Román-Ivorra JA, Alonso A, Martín Mola E, Cantalejo M, Ercole L, Rivero N; study investigators. 2018. [Epub ahead of print].

 

– In vitro comprehensive analysis of VA692 a new chemical entity for the treatment of osteoarthritis. Int Immunopharmacol. Cheleschi S, Calamia V, Fernandez-Moreno M, Biava M, Giordani A, Fioravanti A, Anzini M, Blanco F. 2018 Aug 25;64:86-100. doi: 10.1016/j.intimp.2018.08.025.

 

– Expert Recommendations on the Interleukin 6 Blockade in Patients with Rheumatoid Arthritis. Reumatol Clin. Tornero Molina J, Balsa Criado A, Blanco García F, Blanco Alonso R, Bustabad S, Calvo Alen J, Corominas H, Fernández Nebro A, Román Ivorra JA, Sanmartí R. 2018 Aug 8. pii: S1699-258X(18)30136-0. doi: 10.1016/j.reuma.2018.07.004.

 

– Mitochondria and mitophagy: biosensors for cartilage degradation and osteoarthritis. Osteoarthritis Cartilage. Blanco FJ, Rego-Pérez I. 2018 Aug;26(8):989-991. doi: 10.1016/j.joca.2018.05.018.

 

– Intraneural IFG-1 in Cryopreserved Nerve Isografts Increase Neural Regeneration and Functional Recovery in the Rat Sciatic Nerve. Neurosurgery. González Porto SA, Domenech N, Blanco FJ, Centeno Cortés A, Rivadulla Fernández C, Álvarez Jorge Á, Sánchez Ibáñez J, Rendal Vázquez E. 2018 Jul 27. doi: 10.1093/neuros/nyy339.

 

– Mitochondrial DNA haplogroups associated with MRI-detected structural damage in early knee osteoarthritis. Osteoarthritis Cartilage. Rego-Pérez I, Blanco FJ, Roemer FW, Guermazi A, Ran D, Ashbeck EL, Fernández-Moreno M, Oreiro N, Hannon MJ, Hunter DJ, Kwoh CK. 2018 Jul 20. pii: S1063-4584(18)31368-2. doi: 10.1016/j.joca.2018.06.016.

 

– Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes. Nat Rev Rheumatol. Blanco FJ, Valdes AM, Rego-Pérez I. 2018 Jun;14(6):327-340. doi: 10.1038/s41584-018-0001-0.

 

– Validation study of genetic biomarkers of response to TNF inhibitors in rheumatoid arthritis. PLoS One. Lopez-Rodriguez R, Perez-Pampin E, Marquez A, Blanco FJ, Joven B, Carreira P, Ferrer MA, Caliz R, Valor L, Narvaez J, Cañete JD, Ordoñez MDC, Manrique-Arija S, Vasilopoulos Y, Balsa A, Pascual-Salcedo D, Moreno-Ramos MJ, Alegre-Sancho JJ, Navarro-Sarabia F, Moreira V, Garcia-Portales R, Raya E, Magro-Checa C, Martin J, Gomez-Reino JJ, Gonzalez A. 2018 May 7;13(5):e0196793. doi: 10.1371/journal.pone.0196793. eCollection 2018.

 

– Recommendations for the use of parenteral methotrexate in rheumatic diseases. Reumatol Clin. Tornero Molina J, Calvo Alen J, Ballina J, Belmonte MÁ, Blanco FJ, Caracuel MÁ, Carbonell J, Corominas H, Chamizo E, Hidalgo C, Ivorra JR, Marenco JL, Moreno Muelas JV, Muñoz-Fernández S, Nolla JM, Pérez T, Sanmarti R, Trenor P, Urrego C, Vidal J, Rosas Gomez de Salazar J. 2018 May – Jun;14(3):142-149. doi: 10.1016/j.reuma.2016.12.001.

 

– The addition of albumin improves Schwann cells viability in nerve cryopreservation. Cell Tissue Bank. González Porto SA, Domenech N, González Rodríguez A, Avellaneda Oviedo EM, Blanco FJ, Arufe Gonda MC, Álvarez Jorge Á, Sánchez Ibañez J, Rendal Vázquez E. 2018 Apr 26. doi: 10.1007/s10561-018-9700-7.

 

– What did we learn from ‘omics’ studies in osteoarthritis. Curr Opin Rheumatol. Ruiz-Romero C, Rego-Perez I, Blanco FJ. 2018 Jan;30(1):114-120. doi: 10.1097/BOR.0000000000000460.

2017

– Improved control over MSCs behavior within 3D matrices by using different cell loads in both in vitro and in vivo environments. Lopez-Mendez TB, Santos-Vizcaino E, Blanco FJ, Pedraz JL, Hernandez RM, Orive G. Int J Pharm. 2017 Sep 8;533(1):62-72. doi: 10.1016/j.ijpharm.2017.09.014.

 

– Human Amniotic Mesenchymal Stromal Cells as Favorable Source for Cartilage Repair. Muiños-López E, Hermida-Gómez T, Fuentes-Boquete I, de Toro-Santos J, Blanco FJ, Díaz-Prado SM. Tissue Eng Part A. 2017 Sep;23(17-18):901-912. doi: 10.1089/ten.TEA.2016.0422.

 

– Long-term effects of hydrogen sulfide on the anabolic-catabolic balance of articular cartilage in vitro. Vela-Anero Á, Hermida-Gómez T, Gato-Calvo L, Vaamonde-García C, Díaz-Prado S, Meijide-Faílde R, Blanco FJ, Burguera EF. Nitric Oxide. 2017 Aug 15;70:42-50. doi: 10.1016/j.niox.2017.08.004.

 

– Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib/Ila clinical trial. Alvaro-Garcia JM; Jover JA; Garcia-Vicuna R; Carreno L; Alonso A; Marsal S; Blanco FJ; Martinez-Taboada Victor M; Taylor P; Martin-Martin C; DelaRosa O; Tagarro I; Diaz-Gonzalez F. Annals Of The Rheumatic Diseases. 2017; 76 (1): 196- 202. DOI: 10.1136/annrheumdis-2015-208918.

 

– Secukinumab in active rheumatoid arthritis: A randomized, double-blind placebo and active comparator controlled phase 3 study. Blanco FJ; Moricke R; Dokoupilova E; Codding C; Neal J; Andersson M; Rohrer S; Richards H. Arthritis & Rheumatology (Hoboken, N.J.). 2017.

 

– Hif-1 alpha Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions. Del Rey MJ; Valin A; Usategui A; Garcia-Herrero CM.; Sanchez-Arago M; Cuezva JM; Galindo M; Bravo B; Canete JD; Blanco FJ; Criado, G; Pablos, JL. SCIENTIFIC REPORTS. 2017; 7 (). DOI: 10.1038/s41598-017-03921-4.

 

– Cardiovascular disease in immune-mediated inflammatory diseases: A cross-sectional analysis of 6 cohorts. Fernandez-Gutierrez B; Perrotti PP; Gisbert JP; Domenech E; Fernandez-Nebro A; Canete JD; Ferrandiz C; Tornero J; Garcia-Sanchez V; Panes J; Fonseca E; Blanco FJ; Rodriguez-Moreno J; Carreira P; Julia A; Marsal S; Rodriguez-Rodriguez L. IMID Consortium. MEDICINE. 2017; 96 (26). DOI: 10.1097/MD.0000000000007308.

 

– A replication study and meta-analysis of mitochondrial DNA variants in the radiographic progression of knee osteoarthritis. Fernández-Moreno M; Soto-Hermida A; Vazquez-Mosquera ME; Cortes-Pereira E; Pertega S; Relano S; Oreiro-Villar N; Fernandez-Lopez C; Blanco FJ; Rego-Perez I. Rheumatology (Oxford, England). 2017;   (): – . DOI: .

 

– Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts. A meta-analysis and functional study. Fernandez-Moreno, Mercedes; Soto-Hermida, Angel; Vazquez-Mosquera, Maria E.; Cortes-Pereira, Estefania; Relano, Sara; Hermida-Gomez, Tamara; Pertega, Sonia; Oreiro-Villar, Natividad; Fernandez-Lopez, Carlos; Garesse, Rafael; Blanco, Francisco J.; Rego-Perez, Ignacio . ANNALS OF THE RHEUMATIC DISEASES. 2017;  76 (6): 1114- 1122. DOI: 10.1136/annrheumdis-2016-210131.

 

– Multiplexed mass spectrometry monitoring of biomarker candidates for osteoarthritis. Fernandez-Puente, Patricia; Calamia, Valentina; Gonzalez-Rodriguez, Lucia; Lourido, Lucia; Camacho-Encina, Maria; Oreiro, Natividad; Ruiz-Romero, Cristina; Blanco, Francisco J. . Journal Of Proteomics. 2017;  152 (): 216- 225. DOI: 10.1016/j.jprot.2016.11.012.

 

– Discovery of circulating proteins associated to knee radiographic osteoarthritis. Lourido, Lucia; Ayoglu, Burcu; Fernandez-Tajes, Juan; Oreiro, Natividad; Henjes, Frauke; Hellstroem, Cecilia; Schwenk, Jochen M.; Ruiz-Romero, Cristina; Nilsson, Peter; Blanco, Francisco J. Scientific Reports. 2017; 7 (): – . DOI: 10.1038/s41598-017-00195-8.

 

– Defining the proteomic landscape of rheumatoid arthritis: progress and prospective clinical applications. Lourido, Lucia; Blanco, Francisco J.; Ruiz-Romero, Cristina. EXPERT REVIEW OF PROTEOMICS. 2017; 14 (5): 431- 444. DOI: 10.1080/14789450.2017.1321481.

 

– Hyperlipidemic microenvironment conditionates damage mechanisms in human chondrocytes by oxidative stress. Medina-Luna, Daniel; Guadalupe Santamaria-Olmedo, Monica; Zamudio-Cuevas, Yessica; Martinez-Flores, Karina; Fernandez-Torres, Javier; Angelica Martinez-Nava, Gabriela; Clavijo-Cornejo, Denise; Hernandez-Diaz, Cristina; Olivos-Meza, Anell; Enrique Gomez-Quiroz, Luis; Concepcion Gutierrez-Ruiz, Maria; Pineda, Carlos; Blanco, Francisco; Reginato, Anthony M.; Lopez-Reyes, Alberto. LIPIDS IN HEALTH AND DISEASE. 2017; 16 (): – . DOI: 10.1186/s12944-017-0510-x.

 

– Human amniotic mesenchymal stromal cells as favourable source for cartilage repair. Muinos-Lopez, Emma; Hermida-Gomez, Tamara; Fuentes-Boquete, Isaac; de Toro-Santos, Francisco Javier; Blanco, Francisco J; Diaz-Prado, Silvia Maria. Tissue Engineering. Part A. 2017;   (): – . DOI: 10.1089/ten.TEA.2016.0422.

 

– MALDI mass spectrometry imaging in rheumatic diseases. Rocha, Beatriz; Cillero-Pastor, Berta; Blanco, Francisco J.; Ruiz-Romero, Cristina. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. 2017; 1865 (7): 784- 794. DOI: 10.1016/j.bbapap.2016.10.004.

 

– Mass spectrometry imaging: a novel technology in rheumatology. Rocha, Beatriz; Ruiz-Romero, Cristina; Blanco, Francisco J. Nature Reviews Rheumatology. 2017; 13 (1): 52- 63. DOI: 10.1038/nrrheum.2016.184.

 

– Combined Treatment With Chondroitin Sulfate and Glucosamine Sulfate Shows No Superiority Over Placebo for Reduction of Joint Pain and Functional Impairment in Patients With Knee Osteoarthritis: A Six-Month Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Roman-Blas, Jorge A.; Castaneda, Santos; Sanchez-Pernaute, Olga; Largo, Raquel; Herrero-Beaumont, Gabriel CS GS Combined Therapy Study Grp. ARTHRITIS & RHEUMATOLOGY. 2017; 69 (1): 77- 85. DOI: 10.1002/art.39819.

 

– Hybrid Alginate-Protein-Coated Graphene Oxide Microcapsules Enhance the Functionality of Erythropoietin Secreting C2C12 Myoblasts. Saenz Del Burgo, Laura; Ciriza, Jesus; Acarregui, Argia; Gurruchaga, Haritz; Blanco, Francisco Javier; Orive, Gorka; Hernandez, Rosa Maria; Pedraz, Jose Luis. Molecular Pharmaceutics. 2017; 14 (3): 885- 898. DOI: 10.1021/acs.molpharmaceut.6b01078.

 

– Ovine Mesenchymal Stromal Cells: Morphologic, Phenotypic and Functional Characterization for Osteochondral Tissue Engineering. Sanjurjo-Rodriguez, Clara; Castro-Vinuelas, Rocio; Hermida-Gomez, Tamara; Fernandez-Vazquez, Tania; Fuentes-Boquete, Isaac Manuel; de Toro-Santos, Francisco Javier; Diaz-Prado, Silvia Maria; Blanco-Garcia, Francisco Javier. Plos One. 2017; 12 (1): e0171231- . DOI: 10.1371/journal.pone.0171231.

 

– Screening and Validation of Novel Biomarkers in Osteoarticular Pathologies by Comprehensive Combination of Protein Array Technologies. Sierra-Sanchez, Alvaro; Garrido-Martin, Diego; Lourido, Lucia; Gonzalez-Gonzalez, Maria; Diez, Paula; Ruiz-Romero, Cristina; Sjober, Ronald; Droste, Conrad; De Las Rivas, Javier; Nilsson, Peter; Blanco, Francisco; Fuentes, Manuel. Journal Of Proteome Research. 2017; 16 (5): 1890- 1899. DOI: 10.1021/acs.jproteome.6b00980.

 

– Recommendations for the use of parenteral methotrexate in rheumatic diseases. Tornero Molina, Jesus; Calvo Alen, Jaime; Ballina, Javier; Belmonte, Maria Angeles; Blanco, Francisco J; Caracuel, Miguel Angel; Carbonell, Jordi; Corominas, Hector; Chamizo, Eugenio; Hidalgo, Cristina; Ivorra, Jose Roman; Marenco, Jose Luis; Moreno Muelas, Jose Vicente; Munoz-Fernandez, Santiago; Nolla, Joan M; Perez, Trinidad; Sanmarti, Raimon; Trenor, Pilar; Urrego, Claudia; Vidal, Javier; Rosas Gomez de Salazar, Jose. Reumatologia Clinica. 2017;   (): – . DOI: 10.1016/j.reuma.2016.12.001.

 

– The mitochondrial inhibitor oligomycin induces an inflammatory response in the rat knee joint. Vaamonde-Garcia, Carlos; Loureiro, Jesus; Valcarcel-Ares, Marta N.; Riveiro-Naveira, Romina R.; Ramil-Gomez, Olalla; Hermida-Carballo, Laura; Centeno, Alberto; Meijide-Failde, Rosa; Blanco, Francisco J.; Lopez-Armada, Maria J . BMC MUSCULOSKELETAL DISORDERS. 2017; 18 (): – . DOI: 10.1186/s12891-017-1621-2.

 

– A multicentric study to evaluate the use of relative retention times in targeted proteomics. Vialas, Vital; Colome-Calls, Nuria; Abian, Joaquin; Aloria, Kerman; Alvarez-Llamas, Gloria; Antunez, Oreto; Arizmendi, Jesus M.; Azkargorta, Mikel; Barcelo-Batllori, Silvia; Barderas, Maria G.; Blanco, Francisco; Ignacio Casal, J.; Casas, Vanessa; de la Torre, Carolina; Chicano-Galvez, Eduardo; Elortza, Felix; Espadas, Guadalupe; Estanyol, Josep M.; Fernandez-Irigoyen, Joaquin; Fernandez-Puente, Patricia; Jose Fidalgo, Maria; Fuentes, Manuel; Gay, Marina; Gil, Concha; Hainard, Alexandre; Luisa Hernaez, Maria; Ibarrola, Nieves; Kopylov, Arthur T.; Lario, Antonio; Antonio Lopez, Juan; Lopez-Lucendo, Maria; Marcilla, Miguel; Marina-Ramirez, Anabel; Marko-Varga, Gyorgy; Martin, Luna; Mora, Maria I.; Morato-Lopez, Esperanza; Munoz, Javier; Antonia Odena, Maria; de Oliveira, Eliandre; Orera, Irene; Ortea, Ignacio; Pasquarello, Carla; Ray, Kevin B.; Rezeli, Melinda; Ruppen, Isabel; Sabido, Eduard; Sanchez del Pino, Manuel M.; Sancho, Jaime; Santamaria, Enrique; Vazquez, Jesus; Vilasecar, Marta; Vivanco, Fernando; Walters, James J.; Zgoda, Victor G.; Corrales, Fernando J.; Canals, Francesc; Paradela, Alberto. Journal Of Proteomics. 2017; 152 (): 138- 149. DOI: 10.1016/j.jprot.2016.10.014.

2016

– Urine metabolome profiling of immune-mediated inflammatory diseases. Alonso, Arnald; Julia, Antonio; Vinaixa, Maria; Domenech, Eugeni; Fernandez-Nebro, Antonio; Canete, Juan D.; Ferrandiz, Carlos; Tornero, Jesus; Gisbert, Javier P.; Nos, Pilar; Gutierrez Casbas, Ana; Puig, Lluis; Gonzalez-Alvaro, Isidoro; Pinto-Tasende, Jose A.; Blanco, Ricardo; Rodriguez, Miguel A.; Beltran, Antoni; Correig, Xavier; Marsal, Sara IMID Consortium. BMC MEDICINE. 2016; 14 (): – . DOI: 10.1186/s12916-016-0681-8.

 

– Effectiveness of Tapentadol Prolonged Release (PR) Compared with Oxycodone/Naloxone PR for the Management of Severe Chronic Low Back Pain with a Neuropathic Component: A Randomized, Controlled, Open-Label, Phase 3b/4 Study. Baron, Ralf; Likar, Rudolf; Martin-Mola, Emilio; Blanco, Francisco J.; Kennes, Lieven; Mueller, Matthias; Falke, Dietmar; Steigerwald, Ilona . Pain Practice. 2016; 16 (5): 580- 599. DOI: 10.1111/papr.12308.

 

– Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis. Cavaco, Sofia; Viegas, Carla S. B.; Rafael, Marta S.; Ramos, Acacio; Magalhaes, Joana; Blanco, Francisco J.; Vermeer, Cees; Simes, Dina C. Cellular And Molecular Life Sciences. 2016; 73 (5): 1051- 1065. DOI: 10.1007/s00018-015-2033-9.

 

– Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis and current skin involvement: a phase III, randomised, controlled trial (PALACE 3). Edwards, Christopher J.; Blanco, Francisco J.; Crowley, Jeffrey; Birbara, Charles A.; Jaworski, Janusz; Aelion, Jacob; Stevens, Randall M.; Vessey, Adele; Zhan, Xiaojiang; Bird, Paul . Annals Of The Rheumatic Diseases. 2016; 75 (6): 1065- 1073. DOI: 10.1136/annrheumdis-2015-207963.

 

– Generating Rho-0 Cells Using Mesenchymal Stem Cell Lines. Fernandez-Moreno, Mercedes; Hermida-Gomez, Tamara; Gallardo, M. Esther; Dalmao-Fernandez, Andrea; Rego-Perez, Ignacio; Garesse, Rafael; Blanco, Francisco J. Plos One. 2016; 11 (10): – . DOI: 10.1371/journal.pone.0164199.

 

– 3, 3 ‘, 5-triiodo-L-thyronine Increases In Vitro Chondrogenesis of Mesenchymal Stem Cells From Human Umbilical Cord Stroma Through SRC2. Fernandez-Pernas, Pablo; Fafian-Labora, Juan; Lesende-Rodriguez, Ivan; Mateos, Jesus; De la Fuente, Alexandre; Fuentes, Isaac; De Toro Santos, Javier; Blanco Garcia, Fco; Arufe, Maria C. Journal Of Cellular Biochemistry. 2016; 117 (9): 2097- 2108. DOI: 10.1002/jcb.25515.

 

– Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis. Ferreiro-Iglesias, A.; Montes, A.; Perez-Pampin, E.; Canete, J. D.; Raya, E.; Magro-Checa, C.; Vasilopoulos, Y.; Sarafidou, T.; Caliz, R.; Ferrer, M. A.; Joven, B.; Carreira, P.; Balsa, A.; Pascual-Salcedo, D.; Blanco, F. J.; Moreno-Ramos, M. J.; Fernandez-Nebro, A.; Ordonez, M. C.; Alegre-Sancho, J. J.; Narvaez, J.; Navarro-Sarabia, F.; Moreira, V.; Valor, L.; Garcia-Portales, R.; Marquez, A.; Martin, J.; Gomez-Reino, J. J.; Gonzalez, A. . Pharmacogenomics Journal. 2016; 16 (2): 137- 140. DOI: 10.1038/tpj.2015.29.

 

– Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib. Hochberg, Marc C.; Martel-Pelletier, Johanne; Monfort, Jordi; Moeller, Ingrid; Ramon Castillo, Juan; Arden, Nigel; Berenbaum, Francis; Blanco, Francisco J.; Conaghan, Philip G.; Domenech, Gema; Henrotin, Yves; Pap, Thomas; Richette, Pascal; Sawitzke, Allen; du Souich, Patrick; Pelletier, Jean-Pierre MOVES Invest Grp. Annals Of The Rheumatic Diseases. 2016;  75 (1): 37- 44.

 

– A genome-wide association study identifies a new locus associated with the response to anti-TNF therapy in rheumatoid arthritis. Julia, A.; Fernandez-Nebro, A.; Blanco, F.; Ortiz, A.; Canete, J. D.; Maymo, J.; Alperi-Lopez, M.; Fernandez-Gutierrez, B.; Olive, A.; Corominas, H.; Erra, A.; Acosta-Colman, I.; Alonso, A.; Lopez-Lasanta, M.; Tortosa, R.; Tornero, J.; Marsal, S. . Pharmacogenomics Journal. 2016; 16 (2): 147- 150. DOI: 10.1038/tpj.2015.31.

 

– Identification of IRX1 as a Risk Locus for Rheumatoid Factor Positivity in Rheumatoid Arthritis in a Genome-Wide Association Study. Julia, Antonio; Blanco, Francisco; Fernandez-Gutierrez, Benjamin; Gonzalez, Antonio; Canete, Juan D.; Maymo, Joan; Alperi-Lopez, Mercedes; Olive, Alex; Corominas, Hector; Martinez-Taboada, Victor; Gonzalez-Alvaro, Isidoro; Fernandez-Nebro, Antonio; Erra, Alba; Sanchez-Fernandez, Simon; Alonso, Arnald; Lopez-Lasanta, Maria; Tortosa, Raul; Codo, Laia; Lluis Gelpi, Josep; Garcia-Montero, Andres C.; Bertranpetit, Jaume; Absher, Devin; Myers, Richard M.; Tornero, Jesus; Marsal, Sara. Arthritis & Rheumatology. 2016; 68 (6): 1384- 1391. DOI: 10.1002/art.39591.

 

– A genome-wide association study identifies SLC8A3 as a susceptibility locus for ACPA-positive rheumatoid arthritis. Julia, Antonio; Gonzalez, Isidoro; Fernandez-Nebro, Antonio; Blanco, Francisco; Rodriguez, Luis; Gonzalez, Antonio; Canete, Juan D.; Maymo, Joan; Alperi-Lopez, Mercedes; Olive, Alejandro; Corominas, Hector; Martinez-Taboada, Victor; Erra, Alba; Sanchez-Fernandez, Simon; Alonso, Arnald; Lopez-Lasanta, Maria; Tortosa, Raul; Codo, Laia; Gelpi, Josep Lluis; Garcia-Montero, Andres C.; Bertranpetit, Jaume; Absher, Devin; Bridges, S. Louis, Jr.; Myers, Richard M.; Tornero, Jesus; Marsal, Sara . Rheumatology. 2016; 55 (6): 1106- 1111. DOI: 10.1093/rheumatology/kew035.

 

– A methodological approach based on gold-nanoparticles followed by matrix assisted laser desorption ionization time of flight mass spectrometry for the analysis of urine profiling of knee osteoarthritis. Lopez-Cortes, Ruben; Formigo, Jacobo; Reboiro-Jato, Miguel; Fdez-Riverola, Florentino; Blanco, Francisco J.; Lodeiro, Carlos; Oliveira, Elisabete; Capelo, J. L.; Santos, H. M. . Talanta. 2016; 150 (): 638- 645. DOI: 10.1016/j.talanta.2015.06.043.

 

– IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies. Lopez-Isac, Elena; Martin, Jose-Ezequiel; Assassi, Shervin; Simeon, Carmen P.; Carreira, Patricia; Ortego-Centeno, Norberto; Freire, Mayka; Beltran, Emma; Narvaez, Javier; Alegre-Sancho, Juan J.; Fernandez-Gutierrez, Benjamin; Balsa, Alejandro; Ortiz, Ana M.; Gonzalez-Gay, Miguel A.; Beretta, Lorenzo; Santaniello, Alessandro; Bellocchi, Chiara; Lunardi, Claudio; Moroncini, Gianluca; Gabrielli, Armando; Witte, Torsten; Hunzelmann, Nicolas; Distler, Jorg H. W.; Riekemasten, Gabriella; van der Helm-Van Mil, Annette H.; de Vries-Bouwstra, Jeska; Magro-Checa, Cesar; Voskuyl, Alexandre E.; Vonk, Madelon C.; Molberg, Oyvind; Merriman, Tony; Hesselstrand, Roger; Nordin, Annika; Padyukov, Leonid; Herrick, Ariane; Eyre, Steve; Koeleman, Bobby P. C.; Denton, Christopher P.; Fonseca, Carmen; Radstake, Timothy R. D. J.; Worthington, Jane; Mayes, Maureen D.; Martin, Javier Spanish Scleroderma Grp. Arthritis & Rheumatology. 2016; 68 (9): 2338- 2344. DOI: 10.1002/art.39730.

 

– Secretome analysis of human articular chondrocytes unravels catabolic effects of nicotine on the joint. Lourido, Lucia; Calamia, Valentina; Fernandez-Puente, Patricia; Mateos, Jesus; Oreiro, Natividad; Blanco, Francisco J.; Ruiz-Romero, Cristina. Proteomics Clinical Applications. 2016; 10 (6): 671- 680. DOI: 10.1002/prca.201400186.

 

– Comparable long-term efficacy, as assessed by patient-reported outcomes, safety and pharmacokinetics, of CT-P13 and reference infliximab in patients with ankylosing spondylitis: 54-week results from the randomized, parallel-group PLANETAS study. Park, Won; Yoo, Dae Hyun; Jaworski, Janusz; Brzezicki, Jan; Gnylorybov, Andriy; Kadinov, Vladimir; Goecke Sariego, Irmgadt; Abud-Mendoza, Carlos; Otero Escalante, William Jose; Kang, Seong Wook; Andersone, Daina; Blanco, Francisco; Hong, Seung Suh; Lee, Sun Hee; Braun, Juergen . Arthritis Research & Therapy. 2016; 18 (): – . DOI: 10.1186/s13075-016-0930-4.

 

– A Single Nucleotide Polymorphism in the Il17ra Promoter Is Associated with Functional Severity of Ankylosing Spondylitis. Ramon Vidal-Castineira, Jose; Lopez-Vazquez, Antonio; Diaz-Pena, Roberto; Diaz-Bulnes, Paula; Martinez-Camblor, Pablo; Coto, Eliecer; Coto-Segura, Pablo; Bruges-Armas, Jacome; Antonio Pinto, Jose; Jose Blanco, Francisco; Sanchez, Alejandra; Mulero, Juan; Queiro, Ruben; Lopez-Larrea, Carlos . Plos One. 2016; 11 (7): – . DOI: 10.1371/journal.pone.0158905.

 

– Insulin decreases autophagy and leads to cartilage degradation. Ribeiro, M.; Lopez de Figueroa, P.; Blanco, F. J.; Mendes, A. F.; Carames, B. Osteoarthritis And Cartilage. 2016; 24 (4): 731- 739. DOI: 10.1016/j.joca.2015.10.017.

 

– Diabetes-accelerated experimental osteoarthritis is prevented by autophagy activation. Ribeiro, M.; Lopez de Figueroa, P.; Nogueira-Recalde, U.; Centeno, A.; Mendes, A. F.; Blanco, F. J.; Carames, B. . Osteoarthritis And Cartilage. 2016; 24 (12): 2116- 2125. DOI: 10.1016/j.joca.2016.06.019.

 

– Resveratrol lowers synovial hyperplasia, inflammatory markers and oxidative damage in an acute antigen-induced arthritis model. Riveiro-Naveira, Romina R.; Valcarcel-Ares, Marta N.; Almonte-Becerril, Maylin; Vaamonde-Garcia, Carlos; Loureiro, Jesus; Hermida-Carballo, Laura; Lopez-Pelaez, Eduardo; Blanco, Francisco J.; Lopez-Armada, Maria J. Rheumatology. 2016; 55 (10): 1889- 1900. DOI: 10.1093/rheumatology/kew255.

 

– Identification of Factors Produced and Secreted by Mesenchymal Stromal Cells with the SILAC Method. Rocha, Beatriz; Calamia, Valentina; Blanco, Francisco J; Ruiz-Romero, Cristina. Methods In Molecular Biology (Clifton, N.J.). 2016; 1416 (): 551- 65. DOI: 10.1007/978-1-4939-3584-0_33.

 

– Differentiation of human mesenchymal stromal cells cultured on collagen sponges for cartilage repair. Sanjurjo-Rodirguez, Clara; Helvia Martinez-Sanchez, Adela; Hermida-Gomez, Tamara; Fuentes-Boquete, Isaac; Diaz-Prado, Silvia; Blanco, Francisco J. Histology And Histopathology. 2016; 31 (11): 1221- 1239. DOI: 10.14670/HH-11-754.

 

– European Mitochondrial Haplogroups Impact on Liver Fibrosis Progression Among HCV and HIV/HCV-Coinfected Patients From Northwest Spain. Tabernilla, Andres; Rego-Perez, Ignacio; Grandal, Marta; Pernas, Berta; Pertega, Sonia; Delgado, Manuel; Marino, Ana; Alvarez, Hortensia; Mena, Alvaro; Rodriguez-Osorio, Iria; Domingo Pedreira, Jose; Javier Blanco, Francisco; Poveda, Eva. Jaids-Journal Of Acquired Immune Deficiency Syndromes. 2016; 73 (2): 149- 153. DOI:

 

– A functional variant of TLR10 modifies the activity of NF kappa B and may help predict a worse prognosis in patients with rheumatoid arthritis. Torices, Silvia; Julia, Antonio; Munoz, Pedro; Varela, Ignacio; Balsa, Alejandro; Marsal, Sara; Fernandez-Nebro, Antonio; Blanco, Francisco; Lopez-Hoyos, Marcos; Martinez-Taboada, Victor; Fernandez-Luna, Jose L. . Arthritis Research & Therapy. 2016; 18 (): – . DOI: 10.1186/s13075-016-1113-z.

 

– Translation of clinical problems in osteoarthritis into pathophysiological research goals. van der Kraan, Peter M; Berenbaum, Francis; Blanco, Francisco J; Cosimo, de Bari; Lafeber, Floris; Hauge, Ellen; Higginbottom, Adele; Ioan-Facsinay, Andreea; Loughlin, John; Meulenbelt, Ingrid; Moilanen, Eeva; Pitsillidou, Irene; Tsezou, Aspasia; van Meurs, Joyce; Vincent, Tonia; Wittoek, Ruth; Lories, Rik EULAR Study group in OA (http://www.eular.org/investigative_rheumatology_study_groups.cfm). Rmd Open. 2016; 2 (1): e000224- . DOI: 10.1136/rmdopen-2015-000224.

 

– IDENTIFICATION OF PREDICTIVE BIOMARKERS OF THERAPEUTIC RESPONSE IN KNEE OA: THE MOVES STUDY. Verges, J.; Calamia, V; Mateos, J.; Fernandez, P.; Lourido, L.; Camacho, M.; Oreiro, N.; Raga, A.; Acasuso, M.; Herrero, M.; Martinez, H.; Ruiz, C.; Blanco, F. J. . Basic & Clinical Pharmacology & Toxicology. 2016; 119 (): 25- 25.

 

– Specific premature epigenetic aging of cartilage in osteoarthritis. Vidal-Bralo, Laura; Lopez-Golan, Yolanda; Mera-Varela, Antonio; Rego-Perez, Ignacio; Horvath, Steve; Zhang, Yuhua; del Real, Alvaro; Zhai, Guangju; Blanco, Francisco J.; Riancho, Jose A.; Gomez-Reino, Juan J.; Gonzalez, Antonio . Aging-Us. 2016; 8 (9): 2222- 2231. DOI: 10.18632/aging.101053.

2015

– Variation at FCGR2A and Functionally Related Genes Is Associated with the Response to Anti-TNF Therapy in Rheumatoid Arthritis. Avila-Pedretti, Gabriela; Tornero, Jesus; Fernandez-Nebro, Antonio; Blanco, Francisco; Gonzalez-Alvaro, Isidoro; Canete, Juan D.; Maymo, Joan; Alperiz, Mercedes; Fernandez-Gutierrez, Benjamin; Olive, Alex; Corominas, Hector; Erra, Alba; Aterido, Adria; Lopez Lasanta, Maria; Tortosa, Rauel; Julia, Antonio; Marsal, Sara. Plos One. 2015; 10 (4): – . DOI: 10.1371/journal.pone.0122088.

 

– Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis. Baeten, Dominique; Sieper, Joachim; Braun, Juergen; Baraliakos, Xenofon; Dougados, Maxime; Emery, Paul; Deodhar, Atul; Porter, Brian; Martin, Ruvie; Andersson, Mats; Mpofu, Shephard; Richards, Hanno B. MEASURE 1 & MEASURE 2 Study Grp. New England Journal Of Medicine. 2015; 373 (26): 2534- 2548. DOI: 10.1056/NEJMoa1505066.

 

– Improved prediction of knee osteoarthritis progression by genetic polymorphisms: the Arthrotest Study. Blanco, Francisco J.; Moeller, Ingrid; Romera, Montserrat; Rozadilla, Antoni; Sanchez-Lazaro, Jaime A.; Rodriguez, Arturo; Galvez, Jose; Fores, Joaquim; Monfort, Jordi; Ojeda, Soledad; Moragues, Carme; Angel Caracuel, Miguel; Clavaguera, Teresa; Valdes, Carmen; Maria Soler, Josep; Orellana, Cristobal; Angel Belmonte, Miguel; Martin, Florentina; Gimenez, Sergio; Ucar, Eduardo; Pous, Josep; Bartolome, Nerea; Artieda, Marta; Szczypiorska, Magdalena; Tejedor, Diego; Martinez, Antonio; Montell, Eulalia; Martinez, Helena; Herrero, Marta; Verges, Josep Arthrotest Study Grp. Rheumatology. 2015; 54 (7): 1236- 1243. DOI: 10.1093/rheumatology/keu478.

 

– Alternative protocols to induce chondrogenic differentiation: transforming growth factor-beta superfamily. Cicione, Claudia; Muinos-Lopez, Emma; Hermida-Gomez, Tamara; Fuentes-Boquete, Isaac; Diaz-Prado, Silvia; Blanco, Francisco J. Cell And Tissue Banking. 2015; 16 (2): 195- 207. DOI: 10.1007/s10561-014-9472-7.

 

– Protein classification and distribution in osteoarthritic human synovial tissue by matrix-assisted laser desorption ionization mass spectrometry imaging. Cillero-Pastor, Berta; Eijkel, Gert B.; Blanco, Francisco J.; Heeren, Ron M. A. Analytical And Bioanalytical Chemistry. 2015; 407 (8): 2213- 2222. DOI: 10.1007/s00216-014-8342-2.

 

– Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1. Cortes, Adrian; Pulit, Sara L.; Leo, Paul J.; Pointon, Jenny J.; Robinson, Philip C.; Weisman, Michael H.; Ward, Michael; Gensler, Lianne S.; Zhou, Xiaodong; Garchon, Henri-Jean; Chiocchia, Gilles; Nossent, Johannes; Lie, Benedicte A.; Forre, Oystein; Tuomilehto, Jaakko; Laiho, Kari; Bradbury, Linda A.; Elewaut, Dirk; Burgos-Vargas, Ruben; Stebbings, Simon; Appleton, Louise; Farrah, Claire; Lau, Jonathan; Haroon, Nigil; Mulero, Juan; Blanco, Francisco J.; Gonzalez-Gay, Miguel A.; Lopez-Larrea, C.; Bowness, Paul; Gaffney, Karl; Gaston, Hill; Gladman, Dafna D.; Rahman, Proton; Maksymowych, Walter P.; Crusius, J. Bart A.; van der Horst-Bruinsma, Irene E.; Valle-Onate, Raphael; Romero-Sanchez, Consuelo; Hansen, Inger Myrnes; Pimentel-Santos, Fernando M.; Inman, Robert D.; Martin, Javier; Breban, Maxime; Wordsworth, Bryan Paul; Reveille, John D.; Evans, David M.; de Bakker, Paul I. W.; Brown, Matthew A. . Nature Communications. 2015.

 

– Proteomic Analysis of Connexin 43 Reveals Novel Interactors Related to Osteoarthritis. Gago-Fuentes, Raquel; Fernandez-Puente, Patricia; Megias, Diego; Carpintero-Fernandez, Paula; Mateos, Jesus; Acea, Benigno; Fonseca, Eduardo; Javier Blanco, Francisco; Dolores Mayan, Maria. Molecular & Cellular Proteomics. 2015; 14 (7): 1831- 1845. DOI: 10.1074/mcp.M115.050211.

 

– OARSI Clinical Trials Recommendations: Soluble biomarker assessments in clinical trials in osteoarthritis. Kraus, V. B.; Blanco, F. J.; Englund, M.; Henrotin, Y.; Lohmander, L. S.; Losina, E.; Onnerfjord, P.; Persiani, S. Osteoarthritis And Cartilage. 2015; 23 (5): 686- 697. DOI: 10.1016/j.joca.2015.03.002.

 

– Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use. Kraus, V. B.; Blanco, F. J.; Englund, M.; Karsdal, M. A.; Lohmander, L. S. Osteoarthritis And Cartilage. 2015; 23 (8): 1233- 1241. DOI: 10.1016/j.joca.2015.03.036.

 

– Autophagy Activation and Protection From Mitochondrial Dysfunction in Human Chondrocytes. Lopez de Figueroa, Paloma; Lotz, Martin K.; Blanco, Francisco J.; Carames, Beatriz. Arthritis & Rheumatology. 2015; 67 (4): 966- 976. DOI: 10.1002/art.39025.

 

– Variation at Interleukin-6 Receptor Gene Is Associated to Joint Damage in Rheumatoid Arthritis. Lopez-Lasanta, Maria; Julia, Antonio; Maymo, Joan; Fernandez Gutierrez, Benjamin; Urena, Inmaculada; Blanco, Francisco J.; Canete, Juan D.; Alperi-Lopez, Mercedes; Olive, Alejandro; Corominas, Hector; Tornero, Jesus; Erra, Alba; Almirall, Miriam; Palau, Nuria; Ortiz Garcia, Ana M.; Avila, Gabriela; Rodriguez-Rodriguez, Luis; Alonso, Arnald; Tortosa, Rauel; Gonzalez-Alvaro, Isidoro; Marsal, Sara . Arthritis & Rheumatology. 2015;  67 (): – . DOI: .

 

– Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis. Lopez-Lasanta, Maria; Julia, Antonio; Maymo, Joan; Fernandez-Gutierrez, Benjamin; Urena-Garnica, Inmaculada; Blanco, Francisco J.; Canete, Juan D.; Alperi-Lopez, Mercedes; Olive, Alex; Corominas, Hector; Tornero, Jesus; Erra, Alba; Almirall, Miriam; Palau, Nuria; Ortiz, Ana; Avila, Gabriela; Rodriguez-Rodriguez, Luis; Alonso, Arnald; Tortosa, Rauel; Gonzalez-Alvaro, Isidoro; Marsal, Sara . Arthritis Research & Therapy. 2015; 17 (): – . DOI: 10.1186/s13075-015-0737-8.

 

– Long-Term Safety, Efficacy, and Quality of Life in Patients With Juvenile Idiopathic Arthritis Treated With Intravenous Abatacept for Up to Seven Years. Lovell, Daniel J.; Ruperto, Nicolino; Mouy, Richard; Paz, Eliana; Rubio-Perez, Nadina; Silva, Clovis A.; Abud-Mendoza, Carlos; Burgos-Vargas, Ruben; Gerloni, Valeria; Melo-Gomes, Jose A.; Saad-Magalhaes, Claudia; Chavez-Corrales, J.; Huemer, Christian; Kivitz, Alan; Blanco, Francisco J.; Foeldvari, Ivan; Hofer, Michael; Huppertz, Hans-Iko; Deslandre, Chantal Job; Minden, Kirsten; Punaro, Marilynn; Block, Alan J.; Giannini, Edward H.; Martini, Alberto Pediat Rheumatology Collaborative; Paediat Rheumatology Int Trials Or. Arthritis & Rheumatology. 2015; 67 (10): 2759- 2770. DOI: 10.1002/art.39234.

 

– Effect of the Physicochemical Properties of Pure or Chitosan-Coated Poly(L-Lactic Acid)Scaffolds on the Chondrogenic Differentiation of Mesenchymal Stem Cells from Osteoarthritic Patients. Magalhaes, Joana; Lebourg, Myriam; Deplaine, Harmony; Gomez Ribelles, Jose Luis; Blanco, Francisco J. Tissue Engineering Part A. 2015; 21 (3-4): 716- 728. DOI: 10.1089/ten.tea.2014.0133.

 

– iTRAQ-based analysis of progerin expression reveals mitochondrial dysfunction, reactive oxygen species accumulation and altered proteostasis. Mateos, Jesus; Landeira-Abia, Arancha; Antonio Fafian-Labora, Juan; Fernandez-Pernas, Pablo; Lesende-Rodriguez, Ivan; Fernandez-Puente, Patricia; Fernandez-Moreno, Mercedes; Delmiro, Aitor; Martin, Miguel A.; Blanco, Francisco J.; Arufe, Maria C. Stem Cell Research & Therapy. 2015; 6 (): – . DOI: 10.1186/s13287-015-0110-5.

 

– Articular chondrocyte network mediated by gap junctions: role in metabolic cartilage homeostasis. Mayan, Maria D.; Gago-Fuentes, Raquel; Carpintero-Fernandez, Paula; Fernandez-Puente, Patricia; Filgueira-Fernandez, Purificacion; Goyanes, Noa; Valiunas, Virginijus; Brink, Peter R.; Goldberg, Gary S.; Blanco, Francisco J. Annals Of The Rheumatic Diseases. 2015; 74 (1): 275- 284. DOI: 10.1136/annrheumdis-2013-204244.

 

– Rheumatoid arthritis response to treatment across IgG1 allotype – anti-TNF incompatibility: a case-only study. Montes, Ariana; Perez-Pampin, Eva; Navarro-Sarabia, Federico; Moreira, Virginia; Rodriguez de la Sema, Arturo; Magallares, Berta; Vasilopoulos, Yiannis; Sarafidou, Theologia; Fernandez-Nebro, Antonio; del Carmen Ordonez, Maria; Narvaez, Javier; Canete, Juan D.; Marquez, Ana; Pascual-Salcedo, Dora; Joven, Beatriz; Carreira, Patricia; Moreno-Ramos, Manuel J.; Caliz, Rafael; Angel Ferrer, Miguel; Garcia-Portales, Rosa; Blanco, Francisco J.; Magro, Cesar; Raya, Enrique; Valor, Lara; Alegre-Sancho, Juan J.; Balsa, Alejandro; Martin, Javier; Plant, Darren; Isaacs, John; Morgan, Ann W.; Barton, Anne; Wilson, Anthony G.; Gomez-Reino, Juan J.; Gonzalez, Antonio BRAGGSS. Arthritis Research & Therapy. 2015; 17 (): – . DOI: 10.1186/s13075-015-0571-z.

 

– Characterization of lipidic markers of chondrogenic differentiation using mass spectrometry imaging. Rocha, Beatriz; Cillero-Pastor, Berta; Eijkel, Gert; Bruinen, Anne L.; Ruiz-Romero, Cristina; Heeren, Ron M. A.; Blanco, Francisco J. Proteomics. 2015; 15 (4): 702- 713. DOI: 10.1002/pmic.201400260.

 

– The Spanish biology/disease initiative within the human proteome project: Application to rheumatic diseases. Ruiz-Romero, Cristina; Calamia, Valentina; Pablo Albar, Juan; Ignacio Casal, Jose; Corrales, Fernando J.; Fernandez-Puente, Patricia; Gil, Concha; Mateos, Jesus; Vivanco, Fernando; Blanco, Francisco J. Journal Of Proteomics. 2015; 127 (): 406- 413. DOI: 10.1016/j.jprot.2015.01.023.

 

– Lessons from the proteomic study of osteoarthritis. Ruiz-Romero, Cristina; Fernandez-Puente, Patricia; Calamia, Valentina; Blanco, Francisco J. Expert Review Of Proteomics. 2015; 12 (4): 433- 443. DOI: 10.1586/14789450.2015.1065182.

 

– Mitochondrial DNA haplogroups modulate the radiographic progression of Spanish patients with osteoarthritis. Soto-Hermida, Angel; Fernandez-Moreno, Mercedes; Pertega-Diaz, Sonia; Oreiro, Natividad; Fernandez-Lopez, Carlos; Blanco, Francisco J.; Rego-Perez, Ignacio. Rheumatology International. 2015; 35 (2): 337- 344. DOI: 10.1007/s00296-014-3104-1.

2014

– Multifunctional hydrogel-based scaffold for improving the functionality of encapsulated therapeutic cells and reducing inflammatory response. Acarregui, Argia; Herran, Enara; Igartua, Manoli; Javier Blanco, Francisco; Luis Pedraz, Jose; Orive, Gorka; Maria Hernandez, Rosa. Acta Biomaterialia. 2014; 10 (10): 4206- 4216. DOI: 10.1016/j.actbio.2014.06.038.

 

– Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus. Alonso-Perez, Elisa; Suarez-Gestal, Marian; Calaza, Manuel; Blanco, Francisco J.; Suarez, Ana; Santos, Maria Jose; Papasteriades, Chryssa; Carreira, Patricia; Pullmann, Rudolf; Ordi-Ros, Josep; Marchini, Maurizio; Skopouli, Fotini N.; Bijl, Marc; Barrizone, Nadia; Sebastiani, Gian Domenico; Migliaresi, Sergio; Witte, Torsten; Lauwerys, Bernard R.; Kovacs, Attila; Ruzickova, Sarka; Gomez-Reino, Juan J.; Gonzalez, Antonio European Consortium SLE DNA Collec. Arthritis Research & Therapy. 2014; 16 (3): – . DOI: 10.1186/ar4585.

 

– Tocilizumab in patients with active rheumatoid arthritis and inadequate response to disease-modifying antirheumatic drugs or tumor necrosis factor inhibitors: subanalysis of Spanish results of an open-label study close to clinical practice. Alvaro-Gracia, Jose M; Fernandez-Nebro, Antonio; Garcia-Lopez, Alicia; Guzman, Manuel; Blanco, Francisco J; Navarro, Francisco J; Bustabad, Sagrario; Armendariz, Yolanda; Roman-Ivorra, Jose A ACT SURE. Reumatologia Clinica. 2014; 10 (2): 94- 100. DOI: 10.1016/j.reuma.2013.07.002.

 

– Osteoarthritis: something is moving. Blanco, Francisco J. Reumatologia Clinica. 2014; 10 (1): 4- 5. DOI: 10.1016/j.reuma.2013.12.001.

 

– Osteoarthritis Year in Review 2014: we need more biochemical biomarkers in qualification phase. Blanco, Francisco J. Osteoarthritis And Cartilage. 2014; 22 (12): 2025- 2032. DOI: 10.1016/j.joca.2014.09.009.

 

– Is It Time for Epigenetics in Osteoarthritis? Blanco, Francisco J.; Rego-Perez, Ignacio. Arthritis & Rheumatology. 2014; 66 (9): 2324- 2327. DOI: 10.1002/art.38710.

 

– Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1 beta-stimulated human articular chondrocytes. Burguera, E. F.; Vela-Anero, A.; Magalhaes, J.; Meijide-Failde, R.; Blanco, F. J. . Osteoarthritis And Cartilage. 2014; 22 (7): 1026- 1035. DOI: 10.1016/j.joca.2014.04.031.

 

– A pharmacoproteomic study confirms the synergistic effect of chondroitin sulfate and glucosamine. Calamia, Valentina; Mateos, Jesus; Fernandez-Puente, Patricia; Lourido, Lucia; Rocha, Beatriz; Fernandez-Costa, Carolina; Montell, Eulalia; Verges, Josep; Ruiz-Romero, Cristina; Blanco, Francisco J. . Scientific Reports. 2014; 4 (): – . DOI: 10.1038/srep05069.

 

– A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. Evangelou, Evangelos; Kerkhof, Hanneke J.; Styrkarsdottir, Unnur; Ntzani, Evangelia E.; Bos, Steffan D.; Esko, Tonu; Evans, Daniel S.; Metrustry, Sarah; Panoutsopoulou, Kalliope; Ramos, Yolande F. M.; Thorleifsson, Gudmar; Tsilidis, Konstantinos K.; Arden, Nigel; Aslam, Nadim; Bellamy, Nicholas; Birrell, Fraser; Blanco, Francisco J.; Carr, Andrew; Chapman, Kay; Day-Williams, Aaron G.; Deloukas, Panos; Doherty, Michael; Engstrom, Gunnar; Helgadottir, Hafdis T.; Hofman, Albert; Ingvarsson, Thorvaldur; Jonsson, Helgi; Keis, Aime; Keurentjes, J. Christiaan; Kloppenburg, Margreet; Lind, Penelope A.; McCaskie, Andrew; Martin, Nicholas G.; Milani, Lili; Montgomery, Grant W.; Nelissen, Rob G. H. H.; Nevitt, Michael C.; Nilsson, Peter M.; Ollier, William E. R.; Parimi, Neeta; Rai, Ashok; Ralston, Stuart H.; Reed, Mike R.; Riancho, Jose A.; Rivadeneira, Fernando; Rodriguez-Fontenla, Cristina; Southam, Lorraine; Thorsteinsdottir, Unnur; Tsezou, Aspasia; AWallis, Gillian; Wilkinson, J. Mark; Gonzalez, Antonio; Lane, Nancy E.; Lohmander, L. Stefan; Loughlin, John; Metspalu, Andres; Uitterlinden, Andre G.; Jonsdottir, Ingileif; Stefansson, Kari; Slagboom, P. Eline; Zeggini, Eleftheria; Meulenbelt, Ingrid; Ioannidis, John P. A.; Spector, Tim D.; van Meurs, Joyce B. J.; Valdes, Ana M. arcOGEN Consortium. Annals Of The Rheumatic Diseases. 2014; 73 (12): 2130- 2136. DOI: 10.1136/annrheumdis-2012-203114.

 

– Sequential depletion coupled to C18 sequential extraction as a rapid tool for human serum multiple profiling. Fernandez-Costa, Carolina; Reboiro-Jato, Miguel; Fdez-Riverola, Florentino; Ruiz-Romero, Cristina; Blanco, Francisco J.; Capelo-Martinez, Jose-Luis . Talanta. 2014; 125 (): 189- 195. DOI: 10.1016/j.talanta.2014.02.050.

 

– LC-MALDI-TOF/TOF for shotgun proteomics. Fernandez-Puente, Patricia; Mateos, Jesus; Blanco, Francisco J; Ruiz-Romero, Cristina. Methods In Molecular Biology (Clifton, N.J.). 2014; 1156 (): 27- 38. DOI: 10.1007/978-1-4939-0685-7_2.

 

– Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients. Fernandez-Tajes, Juan; Soto-Hermida, Angel; Vazquez-Mosquera, Maria E.; Cortes-Pereira, Estefania; Mosquera, Alejandro; Fernandez-Moreno, Mercedes; Oreiro, Natividad; Fernandez-Lopez, Carlos; Luis Fernandez, Jose; Rego-Perez, Ignacio; Blanco, Francisco J. Annals Of The Rheumatic Diseases. 2014; 73 (4): 668- 677. DOI:

 

– Lack of replication of interactions between polymorphisms in rheumatoid arthritis susceptibility: case-control study. Ferreiro-Iglesias, Aida; Calaza, Manuel; Perez-Pampin, Eva; Lopez Longo, Francisco J.; Marenco, Jose L.; Blanco, Francisco J.; Narvaez, Javier; Navarro, Federico; Canete, Juan D.; de la Serna, Arturo R.; Gonzalez-Alvaro, Isidoro; Herrero-Beaumont, Gabriel; Pablos, Jose L.; Balsa, Alejandro; Fernandez-Gutierrez, Benjamin; Caliz, Rafael; Gomez-Reino, Juan J.; Gonzalez, Antonio . Arthritis Research & Therapy. 2014; 16 (5): – . DOI: 10.1186/s13075-014-0436-x.

 

– Biochemical evidence for gap junctions and Cx43 expression in immortalized human chondrocyte cell line: a potential model in the study of cell communication in human chondrocytes. Gago-Fuentes, R.; Carpintero-Fernandez, P.; Goldring, M. B.; Brink, P. R.; Mayan, M. D.; Blanco, F. J. . Osteoarthritis And Cartilage. 2014; 22 (4): 586- 590. DOI: 10.1016/j.joca.2014.02.002.

 

– Analysis of Autoantibody Profiles in Osteoarthritis Using Comprehensive Protein Array Concepts. Henjes, Frauke; Lourido, Lucia; Ruiz-Romero, Cristina; Fernandez-Tajes, Juan; Schwenk, Jochen M.; Gonzalez-Gonzalez, Maria; Banco, Francisco J.; Nilsson, Peter; Fuentes, Manuel. Journal Of Proteome Research. 2014; 13 (11): 5218- 5229. DOI: 10.1021/pr500775a.

 

– A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility. Lopez-Isac, Elena; Bossini-Castillo, Lara; Simeon, Carmen P.; Victoria Egurbide, Maria; Jose Alegre-Sancho, Juan; Luis Callejas, Jose; Andres Roman-Ivorra, Jose; Freire, Mayka; Beretta, Lorenzo; Santaniello, Alessandro; Airo, Paolo; Lunardi, Claudio; Hunzelmann, Nicolas; Riemekasten, Gabriela; Witte, Torsten; Kreuter, Alexander; Distler, Joerg H. W.; Schuerwegh, Annemie J.; Vonk, Madelon C.; Voskuyl, Alexandre E.; Shiels, Paul G.; van Laar, Jacob M.; Fonseca, Carmen; Denton, Christopher; Herrick, Ariane; Worthington, Jane; Assassi, Shervin; Koeleman, Bobby P.; Mayes, Maureen D.; Radstake, Timothy R. D. J.; Martin, Javier Spanish Scleroderma Grp. Arthritis Research & Therapy. 2014; 16 (1): – . DOI: 10.1186/ar4432.

 

– Quantitative Proteomic Profiling of Human Articular Cartilage Degradation in Osteoarthritis. Lourido, Lucia; Calamia, Valentina; Mateos, Jesus; Fernandez-Puente, Patricia; Fernandez-Tajes, Juan; Banco, Francisco J.; Ruiz-Romero, Cristina. Journal Of Proteome Research. 2014; 13 (12): 6096- 6106. DOI: 10.1021/pr501024p.

 

– Poly(2-ethyl-(2-pyrrolidone) methacrylate) and hyaluronic acid-based hydrogels for the engineering of a cartilage-like tissue using bovine articular chondrocytes. Magalhaes, Joana; Crawford, Aileen; Hatton, Paul V.; Blanco, Francisco J.; Roman, Julio San . Journal Of Bioactive And Compatible Polymers. 2014; 29 (6): 545- 559. DOI: 10.1177/0883911514555609.

 

– Cryoconservation of Peptide Extracts from Trypsin Digestion of Proteins for Proteomic Analysis in a Hospital Biobank Facility. Mateos, Jesus; Pintor-Iglesias, Alejandra; Fernandez-Puente, Patricia; Garcia-Camba, Marta; Ruiz-Romero, Cristina; Domenech, Nieves; Blanco, Francisco J. Journal Of Proteome Research. 2014; 13 (4): 1930- 1937. DOI: 10.1021/pr401046u.

 

– Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis. Mayes, Maureen D.; Bossini-Castillo, Lara; Gorlova, Olga; Martin, Jose Ezequiel; Zhou, Xiaodong; Chen, Wei V.; Assassi, Shervin; Ying, Jun; Tan, Filemon K.; Arnett, Frank C.; Reveille, John D.; Guerra, Sandra; Terue, Maria; Carmona, Francisco David; Gregersen, Peter K.; Lee, Annette T.; Lopez-Isac, Elena; Ochoa, Eguzkine; Carreira, Patricia; Simeon, Carmen Pilar; Castellvi, Ivan; Angel Gonzalez-Gay, Miguel; Zhernakova, Alexandra; Padyukov, Leonid; Aarcon-Riquelme, Marta; Wijmenga, Cisca; Brown, Matthew; Beretta, Lorenzo; Riemekasten, Gabriela; Witte, Torsten; Hunzelmann, Nicolas; Kreuter, Alexander; Distler, Jorg H. W.; Voskuy, Alexandre E.; Schuerwegh, Annemie J.; Hesselstrand, Roger; Nordin, Annika; Airo, Paolo; Lunardi, Claudio; Shiels, Paul; van Laar, Jacob M.; Herrick, Ariane; Worthington, Jane; Denton, Christopher; Wigley, Fredrick M.; Hummers, Laura K.; Varga, John; Hinchcliff, Monique E.; Baron, Murray; Hudson, Marie; Pope, Janet E.; Furst, Daniel E.; Khanna, Dinesh; Phillips, Kristin; Schiopu, Elena; Segal, Barbara M.; Molitor, Jerry A.; Silver, Richard M.; Steen, Virginia D.; Simms, Robert W.; Lafyatis, Robert A.; Fessler, Barn I. J.; Frech, Tracy M.; AlKassab, Firas; Docherty, Peter; Kaminska, Elzbieta; Khalidi, Nader; Jones, Henry Niall; Markland, Janet; Robinson, David; Broen, Jasper; Radstake, Timothy R. D. J.; Fonseca, Carmen; Koeleman, Bobby P.; Martin, Javier Spanish Scleroderma Grp. American Journal Of Human Genetics. 2014; 94 (1): 47- 61. DOI: 10.1016/j.ajhg.2013.12.002.

 

– Secretome Analysis of Human Mesenchymal Stem Cells Undergoing Chondrogenic Differentiation. Rocha, Beatriz; Calamia, Valentina; Casas, Vanessa; Carrascal, Montserrat; Blanco, Francisco J.; Ruiz-Romero, Cristina . Journal Of Proteome Research. 2014; 13 (2): 1045- 1054. DOI: 10.1021/pr401030n.

 

– Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies. Rodriguez-Fontenla, Cristina; Calaza, Manuel; Evangelou, Evangelos; Valdes, Ana M.; Arden, Nigel; Blanco, Francisco J.; Carr, Andrew; Chapman, Kay; Deloukas, Panos; Doherty, Michael; Esko, Tonu; Garces Aleta, Carlos M.; Gomez-Reino Carnota, Juan J.; Helgadottir, Hafdis; Hofman, Albert; Jonsdottir, Ingileif; Kerkhof, Hanneke J. M.; Kloppenburg, Margreet; McCaskie, Andrew; Ntzani, Evangelia E.; Ollier, William E. R.; Oreiro, Natividad; Panoutsopoulou, Kalliope; Ralston, Stuart H.; Ramos, Yolande F.; Riancho, Jose A.; Rivadeneira, Fernando; Eline Slagboom, P.; Styrkarsdottir, Unnur; Thorsteinsdottir, Unnur; Thorleifsson, Gudmar; Tsezou, Aspasia; Uitterlinden, Andre G.; Wallis, Gillian A.; Wilkinson, J. Mark; Zhai, Guangju; Zhu, Yanyan; Felson, David T.; Ioannidis, John P. A.; Loughlin, John; Metspalu, Andres; Meulenbelt, Ingrid; Stefansson, Kari; van Meurs, Joyce B.; Zeggini, Eleftheria; Spector, Timothy D.; Gonzalez, Antonio arcOGEN Consortium. Arthritis & Rheumatology. 2014; 66 (4): 940- 949. DOI: 10.1002/art.38300.

 

– Influence of Flap Prefabrication on Seeding of Subcutaneously Injected Mesenchymal Stem Cells in Microvascular Beds in Rats. Rodriguez-Lorenzo, Andres; Arufe, Maria C.; de la Fuente, Alexandre; Fernandez, Fernando; Blanco, Francisco. Annals Of Plastic Surgery. 2014; 73 (2): 234- 238. DOI: 10.1097/SAP.0000000000000074.

 

– Surfing Transcriptomic Landscapes. A Step beyond the Annotation of Chromosome 16 Proteome. Segura, Victor; Alberto Medina-Aunon, Juan; Mora, Maria I.; Martinez-Bartolome, Salvador; Abian, Joaquin; Aloria, Kerman; Antunez, Oreto; Arizmendi, Jesus M.; Azkargorta, Mikel; Barcelo-Batllori, Silvia; Beaskoetxea, Jabier; Bech-Serra, Joan J.; Blance, Francisco; Monteiro, Mariana B.; Caceres, David; Canals, Francesc; Carrascal, Monserrat; Ignacio Casal, Jose; Clemente, Felipe; Colome, Nuria; Dasilva, Noelia; Diaz, Paula; Elortza, Felix; Fernandez-Puente, Patricia; Fuentes, Manuel; Gallardo, Oscar; Gharbi, Severine I.; Gil, Concha; Gonzalez-Tejedo, Carmen; Luisa Hernaez, Maria; Lombardia, Manuel; Lopez-Lucendo, Maria; Marcilla, Miguel; Mato, Jose M.; Mendes, Marta; Oliveira, Eliandre; Orera, Irene; Pascual-Montano, Alberto; Prieto, Gorka; Ruiz-Romero, Cristina; Sanchez del Pino, Manuel M.; Tabas-Madrid, Daniel; Valero, Maria L.; Vialas, Vital; Villanueva, Joan; Pablo Albar, Juan; Corrales, Fernando J. Journal Of Proteome Research. 2014; 13 (1): 158- 172. DOI: 10.1021/pr400721r.

 

– mtDNA haplogroups and osteoarthritis in different geographic populations. Soto-Hermida, A.; Fernandez-Moreno, M.; Oreiro, N.; Fernandez-Lopez, C.; Rego-Perez, I.; Blanco, F. J. . Mitochondrion. 2014; 15 (): 18- 23. DOI: 10.1016/j.mito.2014.03.001.

 

– Mitochondrial DNA (mtDNA) Haplogroups Influence the Progression of Knee Osteoarthritis. Data from the Osteoarthritis Initiative (OAI). Soto-Hermida, Angel; Fernandez-Moreno, Mercedes; Oreiro, Natividad; Fernandez-Lopez, Carlos; Pertega, Sonia; Cortes-Pereira, Estefania; Rego-Perez, Ignacio; Blanco, Francisco J. Plos One. 2014; 9 (11): – . DOI: 10.1371/journal.pone.0112735.

 

– Individual telomere length decay in patients with spondyloarthritis. Tamayo, Maria; Pertega, Sonia; Mosquera, Alejandro; Rodriguez, Montserrat; Blanco, Francisco J.; Luis Fernandez- Mutation Research-Fundamental And Molecular Mechanisms Of Mutagenesis. Sueiro, Jose; Gosalvez, Jaime; Luis Fernandez, Jose. 2014; 765 (): 1- 5. DOI: 10.1016/j.mrfmmm.2014.04.006.

 

– Mitochondrial dysfunction promotes and aggravates the inflammatory response in normal human synoviocytes. Valcarcel-Ares, Marta N.; Riveiro-Naveira, Romina R.; Vaamonde-Garcia, Carlos; Loureiro, Jesus; Hermida-Carballo, Laura; Blanco, Francisco J.; Lopez-Armada, Maria J. Rheumatology. 2014; 53 (7): 1332- 1343. DOI: 10.1093/rheumatology/keu016.

 

– 2-(Dimethylamino)ethyl Methacrylate/(2-Hydroxyethyl) Methacrylate/alpha-Tricalcium Phosphate Cryogels for Bone Repair, Preparation and Evaluation of the Biological Response of Human Trabecular Bone-Derived Cells and Mesenchymal Stem Cells. Volkmer, Tiago; Magalhaes, Joana; Sousa, Vania; Santos, Luis A.; Burguera, Elena F.; Blanco, Francisco J.; San Roman, Julio; Rodriguez-Lorenzo, Luis M. Polymers. 2014; 6 (10): 2510- 2525. DOI: 10.3390/polym6102510.

2013

– Hydrogel-Based Scaffolds for Enclosing Encapsulated Therapeutic Cells. Acarregui, Argia; Luis Pedraz, Jose; Javier Blanco, Francisco; Maria Hernandez, Rosa; Orive, Gorka. Biomacromolecules. 2013; 14 (2): 322- 330. DOI: 10.1021/bm301690a.

 

– GWAS replication study confirms the association of PDE3A-SLCO1C1 with anti-TNF therapy response in rheumatoid arthritis. Acosta-Colman, Isabel; Palau, Nuria; Tornero, Jesus; Fernandez-Nebro, Antonio; Blanco, Francisco; Gonzalez-Alvaro, Isidoro; Canete, Juan D.; Maymo, Joan; Ballina, Javier; Fernandez-Gutierrez, Benjamin; Olive, Alex; Corominas, Hector; Erra, Alba; Canela-Xandri, Oriol; Alonso, Arnald; Lopez Lasanta, Maria; Tortosa, Rauel; Julia, Antonio; Marsal, Sara . Pharmacogenomics. 2013; 14 (7): 727- 734. DOI: 10.2217/PGS.13.60.

 

– New targets for disease modifying osteoarthritis drugs: chondrogenesis and Runx1. Blanco, Francisco J.; Ruiz-Romero, Cristina. Annals Of The Rheumatic Diseases. 2013; 72 (5): 631- 634. DOI: 10.1136/annrheumdis-2012-201745.

 

– Effects of Severe Hypoxia on Bone Marrow Mesenchymal Stem Cells Differentiation Potential. Cicione, Claudia; Muinos-Lopez, Emma; Hermida-Gomez, Tamara; Fuentes-Boquete, Isaac; Diaz-Prado, Silvia; Blanco, Francisco J. Stem Cells International. 2013;   (): – . DOI: 10.1155/2013/232896.

 

– Matrix-assisted laser desorption ionization imaging mass spectrometry: A new methodology to study human osteoarthritic cartilage. Cillero-Pastor, Berta; Eijkel, Gert B.; Kiss, Andras; Blanco, Francisco J.; Heeren, Ron M. A. Arthritis And Rheumatism. 2013; 65 (3): 710- 720. DOI: 10.1002/art.37799.

 

– Mitochondrial respiratory chain dysfunction modulates metalloproteases -1,-3 and -13 in human normal chondrocytes in culture. Cillero-Pastor, Berta; Rego-Perez, Ignacio; Oreiro, Natividad; Fernandez-Lopez, Carlos; Blanco, Francisco J. Bmc Musculoskeletal Disorders. 2013; 14 (): – . DOI: 10.1186/1471-2474-14-235.

 

– Nitric oxide compounds have different effects profiles on human articular chondrocyte metabolism. de Andres, Maria C.; Maneiro, Emilia; Martin, Miguel A.; Arenas, Joaquin; Blanco, Francisco J. Arthritis Research & Therapy. 2013; 15 (5): – . DOI: 10.1186/ar4295.

 

– Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in Spanish population. Fernandez-Caggiano, M.; Barallobre-Barreiro, J.; Rego-Perez, I.; Crespo-Leiro, M. G.; Paniagua, M. J.; Grille, Z.; Blanco, F. J.; Domenech, N. Mitochondrion. 2013; 13 (4): 263- 268. DOI: 10.1016/j.mito.2013.03.005.

 

– An assessment of the indirect high intensity ultrasonic assisted cleavage of complex proteomes with immobilized trypsin. Fernandez-Costa, C.; Ruiz-Romero, C.; Blanco, F. J.; Santos, H. M.; Capelo, J. L. Talanta. 2013; 106 (): 163- 168. DOI: 10.1016/j.talanta.2012.12.022.

 

– Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial. Gabay, Cem; Emery, Paul; van Vollenhoven, Ronald; Dikranian, Ara; Alten, Rieke; Pavelka, Karel; Klearman, Micki; Musselman, David; Agarwal, Sunil; Green, Jennifer; Kavanaugh, Arthur ADACTA Study Investigators. Lancet. 2013; 381 (9877): 1541- 1550. DOI: 10.1016/S0140-6736(13)60250-0.

 

– Mineralization of porous hydrogels based on semi-interpenetrated networks of poly[2-ethyl(2-pyrrolidone) methacrylate] and hyaluronic acid in simulated body fluid. Magalhaes, Joana; Crawford, Aileen; Hatton, Paul V.; Blanco, Francisco J.; San Roman, Julio. Journal Of Bioactive And Compatible Polymers. 2013; 28 (5): 468- 480. DOI: 10.1177/0883911513494618.

 

– Synthesis and characterization of sensitive hydrogels based on semi-interpenetrated networks of poly[2-ethyl-(2-pyrrolidone) methacrylate] and hyaluronic acid. Magalhaes, Joana; Sousa, Rui A.; Mano, Joao F.; Reis, Rui L.; Blanco, Francisco J.; San Roman, Julio . Journal Of Biomedical Materials Research Part A. 2013; 101 (1): 157- 166. DOI: 10.1002/jbm.a.34312.

 

– 110) Lamin A deregulation in human mesenchymal stem cells promotes an impairment in their chondrogenic potential and imbalance in their response to oxidative stress. Mateos, Jesus; De la Fuente, Alexandre; Lesende-Rodriguez, Ivan; Fernandez-Pernas, Pablo; Arufe, Maria C.; Blanco, Francisco J. Stem Cell Research. 2013; 11 (3): 1137- 1148. DOI: 10.1016/j.scr.2013.07.004.

 

– Human Articular Chondrocytes Express Multiple Gap Junction Proteins Differential Expression of Connexins in Normal and Osteoarthritic Cartilage. Mayan, Maria D.; Carpintero-Fernandez, Paula; Gago-Fuentes, Raquel; Martinez-de-Ilarduya, Oskar; Wang, Hong-Zhang; Valiunas, Virginijus; Brink, Peter; Blanco, Francisco J. American Journal Of Pathology. 2013; 182 (4): 1337- 1346. DOI: 10.1016/j.ajpath.2012.12.018.

 

– Economic Evaluation of Rheumathoid Arthritis Monotherapy with Tocilizumab and Adalimumab. Navarro Sarabia, Federico; Blanco, Francisco J.; Alvaro Gracia, Jose Ma; Gracia Meijide, Juan A.; Luis Poveda, Jose; Rubio-Rodriguez, Dario; Rubio-Terres, Carlos. Revista Espanola De Salud Publica. 2013; 87 (4): 343- 350. DOI: .

 

– Mitochondrial genetics and osteoarthritis. Rego-Perez, Ignacio; Fernandez-Moreno, Mercedes; Soto-Hermida, Angel; Fenandez-Lopez, Carlos; Oreiro, Natividad; Blanco, Francisco J. Frontiers In Bioscience (Scholar Edition). 2013; 5 (): 360- 8. DOI:

 

– Achievements and Challenges of Proteomics in the Study of Rheumatoid Arthritis. Ruiz-Romero, Cristina; Blanco, Francisco J. Current Topics In Medicinal Chemistry. 2013; 13 (6): 732- 742. DOI:

 

– Spanish Human Proteome Project: Dissection of Chromosome 16. Segura, V.; Medina-Aunon, J. A.; Guruceaga, E.; Gharbi, S. I.; Gonzalez-Tejedo, C.; Sanchez del Pino, M. M.; Canals, F.; Fuentes, M.; Ignacio Casal, J.; Martinez-Bartolome, S.; Elortza, F.; Mato, J. M.; Arizmendi, J. M.; Abian, J.; Oliveira, E.; Gil, C.; Vivanco, F.; Blanco, F.; Albar, J. P.; Corrales, F. J. Journal Of Proteome Research. 2013; 12 (1): 112- 122. DOI: 10.1021/pr300898u.

2012

– Further Evidence of Subphenotype Association with Systemic Lupus Erythematosus Susceptibility Loci: European Cases Only Study. Alonso-Perez, Elisa; Suarez-Gestal, Marian; Calaza, Manuel; Ordi-Ros, Josep; Balada, Eva; Bijl, Marc; Papasteriades, Chryssa; Carreira, Patricia; Skopouli, Fotini N.; Witte, Torsten; Endreffy, Emoeke; Marchini, Maurizio; Migliaresi, Sergio; Sebastiani, Gian Domenico; Santos, Maria Jose; Suarez, Ana; Blanco, Francisco J.; Barizzone, Nadia; Pullmann, Rudolf; Ruzickova, Sarka; Lauwerys, Bernard R.; Gomez-Reino, Juan J.; Gonzalez, Antonio European Consortium SLE DNA Collec. Plos One. 2012; 7 (9): – . DOI: 10.1371/journal.pone.0045356.

 

– Bias in effect size of systemic lupus erythematosus susceptibility loci across Europe: a case-control study. Alonso-Perez, Elisa; Suarez-Gestal, Marian; Calaza, Manuel; Sebastiani, Gian Domenico; Pullmann, Rudolf; Papasteriades, Chryssa; Kovacs, Attila; Skopouli, Fotini N.; Bijl, Marc; Suarez, Ana; Marchini, Maurizio; Migliaresi, Sergio; Carreira, Patricia; Ordi-Ros, Josep; Witte, Torsten; Ruzickova, Sarka; Santos, Maria Jose; Barizzone, Nadia; Blanco, Francisco J.; Lauwerys, Bernard R.; Gomez-Reino, Juan J.; Gonzalez, Antonio European Consortium. Arthritis Research & Therapy. 2012; 14 (2): – . DOI: 10.1186/ar3818.

 

– OSTEOARTHRITIS Metabolomic characterization of metabolic phenotypes in OA. Blanco, Francisco J.; Ruiz-Romero, Cristina. Nature Reviews Rheumatology. 2012; 8 (3): 130- 132. DOI: 10.1038/nrrheum.2012.11.

 

– Pharmacoproteomic Study of Three Different Chondroitin Sulfate Compounds on Intracellular and Extracellular Human Chondrocyte Proteomes. Calamia, Valentina; Fernandez-Puente, Patricia; Mateos, Jesus; Lourido, Lucia; Rocha, Beatriz; Montell, Eulalia; Verges, Josep; Ruiz-Romero, Cristina; Blanco, Francisco J. Molecular & Cellular Proteomics. 2012; 11 (6): – . DOI: 10.1074/mcp.M111.013417.

 

– Secretome analysis of chondroitin sulfate-treated chondrocytes reveals anti-angiogenic, anti-inflammatory and anti-catabolic properties. Calamia, Valentina; Lourido, Lucia; Fernandez-Puente, Patricia; Mateos, Jesus; Rocha, Beatriz; Montell, Eulalia; Verges, Josep; Ruiz-Romero, Cristina; Blanco, Francisco J. Arthritis Research & Therapy. 2012; 14 (5): – . DOI: 10.1186/ar4040.

 

– The C677T polymorphism in the MTHFR gene is associated with the toxicity of methotrexate in a Spanish rheumatoid arthritis population. Caliz, R.; del Amo, J.; Balsa, A.; Blanco, F.; Silva, L.; Sanmarti, R.; Martinez, F. G.; Collado, M. D.; del Carmen Ramirez, M.; Tejedor, D.; Artieda, M.; Pascual-Salcedo, D.; Oreiro, N.; Andreu, J. L.; Graell, E.; Simon, L.; Martinez, A.; Mulero, J. Scandinavian Journal Of Rheumatology. 2012; 41 (1): 10- 14. DOI: 10.3109/03009742.2011.617312.

 

– Autophagy activation by rapamycin reduces severity of experimental osteoarthritis. Carames, Beatriz; Hasegawa, Akihiko; Taniguchi, Noboru; Miyaki, Shigeru; Blanco, Francisco J.; Lotz, Martin. Annals Of The Rheumatic Diseases. 2012; 71 (4): 575- 581. DOI: 10.1136/annrheumdis-2011-200557.

 

– Mechanical Injury Suppresses Autophagy Regulators and Pharmacologic Activation of Autophagy Results in Chondroprotection. Carames, Beatriz; Taniguchi, Noboru; Seino, Daisuke; Blanco, Francisco J.; D’Lima, Darryl; Lotz, Martin. Arthritis And Rheumatism. 2012; 64 (4): 1182- 1192. DOI: 10.1002/art.33444.

 

– Influence of the IL6 Gene in Susceptibility to Systemic Sclerosis. Carmen Cenit, Maria; Simeon, Carmen P.; Vonk, Madelon C.; Callejas-Rubio, Jose L.; Espinosa, Gerard; Carreira, Patricia; Blanco, Francisco J.; Narvaez, Javier; Tolosa, Carlos; Roman-Ivorra, Jose A.; Gomez-Garcia, Inmaculada; Garcia-Hernandez, Francisco J.; Gallego, Maria; Garcia-Portales, Rosa; Victoria Egurbide, Maria; Fonollosa, Vicente; Garcia de la Pena, Paloma; Lopez-Longo, Francisco J.; Gonzalez-Gay, Miguel A.; Hesselstrand, Roger; Riemekasten, Gabriela; Witte, Torsten; Voskuyl, Alexandre E.; Schuerwegh, Annemie J.; Madhok, Rajan; Fonseca, Carmen; Denton, Christopher; Nordin, Annika; Palm, Oyvind; van Laar, Jacob M.; Hunzelmann, Nicolas; Distler, Joerg H. W.; Kreuter, Alexander; Herrick, Ariane; Worthington, Jane; Koeleman, Bobby P.; Radstake, Timothy R. D. J.; Martin, Javier Spanish Scleroderma Grp. Journal Of Rheumatology. 2012; 39 (12): 2294- 2302. DOI: 10.3899/jrheum.120506.

 

– Time-of-Flight Secondary Ion Mass Spectrometry-Based Molecular Distribution Distinguishing Healthy and Osteoarthritic Human Cartilage. Cillero-Pastor, Berta; Eijkel, Gert; Kiss, Andras; Blanco, Francisco J.; Heeren, Ron M. A. . Analytical Chemistry. 2012; 84 (21): 8909- 8916. DOI: 10.1021/ac301853q.

 

– Dimethylarginine dimethylaminohydrolase 2, a newly identified mitochondrial protein modulating nitric oxide synthesis in normal human chondrocytes. Cillero-Pastor, Berta; Mateos, Jesus; Fernandez-Lopez, Carlos; Oreiro, Natividad; Ruiz-Romero, Cristina; Blanco, Francisco J. Arthritis And Rheumatism. 2012; 64 (1): 204- 212. DOI: 10.1002/art.30652.

 

– Evaluation of a Shared Autoimmune Disease-associated Polymorphism of TRAF6 in Systemic Sclerosis and Giant Cell Arthritis. David Carmona, F.; Serrano, Aurora; Rodriguez-Rodriguez, Luis; Luis Callejas, Jose; Simeon, Carmen P.; Carreira, Patricia; Castaneda, Santos; Solans, Roser; Blanco, Ricardo; Gonzalez-Gay, Miguel A.; Martin, Javier Spanish Scleroderma Grp; Spanish Giant Cell Arteritis Grp. Journal Of Rheumatology. 2012; 39 (6): 1275- 1279. DOI: 10.3899/jrheum.120038.

 

– Proteome Analysis During Chondrocyte Differentiation in a New Chondrogenesis Model Using Human Umbilical Cord Stroma Mesenchymal Stem Cells. De la Fuente, Alexandre; Mateos, Jesus; Lesende-Rodriguez, Ivan; Calamia, Valentina; Fuentes-Boquete, Isaac; de Toro, Francisco J.; Arufe, Maria C.; Blanco, Francisco J. Molecular & Cellular Proteomics. 2012; 11 (2): – . DOI: 10.1074/mcp.M111.010496.

 

– Transcriptome analysis reveals specific changes in osteoarthritis synovial fibroblasts. Del Rey, Manuel J.; Usategui, Alicia; Izquierdo, Elena; Canete, Juan D.; Blanco, Francisco J.; Criado, Gabriel; Pablos, Jose L. Annals Of The Rheumatic Diseases. 2012; 71 (2): 275- 280. DOI: 10.1136/annrheumdis-2011-200281.

 

– Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes. Diaz-Prado, Silvia; Cicione, Claudia; Muinos-Lopez, Emma; Hermida-Gomez, Tamara; Oreiro, Natividad; Fernandez-Lopez, Carlos; Blanco, Francisco J. . Bmc Musculoskeletal Disorders. 2012; 13 (): – . DOI: 10.1186/1471-2474-13-144.

 

– Culture of limbal stem cells on human amniotic membrane. Esther Rendal-Vazquez, Ma; San-Luis-Verdes, Anahi; Teresa Yebra-Pimentel-Vilar, Ma; Lopez-Rodriguez, Isabel; Domenech-Garcia, Nieves; Andion-Nunez, Candido; Blanco-Garcia, Francisco. Cell And Tissue Banking. 2012; 13 (3): 513- 519. DOI: 10.1007/s10561-012-9300-x.

 

– Mitochondrial Haplogroups H and J: Risk and Protective Factors for Ischemic Cardiomyopathy. Fernandez-Caggiano, Mariana; Barallobre-Barreiro, Javier; Rego-Perez, Ignacio; Crespo-Leiro, Maria G.; Jesus Paniagua, Maria; Grille, Zulaika; Blanco, Francisco J.; Domenech, Nieves. Plos One. 2012; 7 (8): – . DOI: 10.1371/journal.pone.0044128.

 

– Sequential depletion of human serum for the search of osteoarthritis biomarkers. Fernandez-Costa, Carolina; Calamia, Valentina; Fernandez-Puente, Patricia; Capelo-Martinez, Jose-Luis; Ruiz-Romero, Cristina; Blanco, Francisco J. Proteome Science. 2012; 10 (): – . DOI: 10.1186/1477-5956-10-55.

 

– Mitochondrial haplogroups define two phenotypes of osteoarthritis. Fernandez-Moreno, Mercedes; Soto-Hermida, Angel; Oreiro, Natividad; Pertega, Sonia; Fenandez-Lopez, Carlos; Rego-Perez, Ignacio; Blanco, Francisco J. Frontiers In Physiology. 2012; 3 (): – . DOI: 10.3389/fphys.2012.00129.

 

– Differential protein profiling of synovial fluid from rheumatoid arthritis and osteoarthritis patients using LC-MALDI TOF/TOF. Mateos, Jesus; Lourido, Lucia; Fernandez-Puente, Patricia; Calamia, Valentina; Fernandez-Lopez, Carlos; Oreiro, Natividad; Ruiz-Romero, Cristina; Blanco, Francisco J. Journal Of Proteomics. 2012; 75 (10): 2869- 2878. DOI: 10.1016/j.jprot.2011.12.042.

 

– Cryopreservation effect on proliferative and chondrogenic potential of human chondrocytes isolated from superficial and deep cartilage. Muinos-Lopez, Emma; Rendal-Vazquez, M Esther; Hermida-Gomez, Tamara; Fuentes-Boquete, Isaac; Diaz-Prado, Silvia; Blanco, Francisco J. The Open Orthopaedics Journal. 2012; 6 (): 150- 9. DOI: 10.2174/1874325001206010150.

 

– In vitro repair model of focal articular cartilage defects in humans. Prado, Diaz; Fuentes-Boquete, I M; Blanco, F J. Methods In Molecular Biology (Clifton, N.J.). 2012; 885 (): 251- 61. DOI: 10.1007/978-1-61779-845-0_16.

 

– Metabolic Labeling of Human Bone Marrow Mesenchymal Stem Cells for the Quantitative Analysis of their Chondrogenic Differentiation. Rocha, Beatriz; Calamia, Valentina; Mateos, Jesus; Fernandez-Puente, Patricia; Blanco, Francisco J.; Ruiz-Romero, Cristina. Journal Of Proteome Research. 2012; 11 (11): 5350- 5361. DOI: 10.1021/pr300572r.

 

– School children’s backpacks, back pain and back pathologies. Rodriguez-Oviedo, Paloma; Ruano-Ravina, Alberto; Perez-Rios, Monica; Blanco Garcia, Francisco; Gomez-Fernandez, Dorotea; Fernandez-Alonso, Anselmo; Carreira-Nunez, Isabel; Garcia-Pacios, Pilar; Turiso, Javier. Archives Of Disease In Childhood. 2012; 97 (8): 730- 732. DOI: 10.1136/archdischild-2011-301253.

 

– Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis. Teruel, Maria; Simeon, Carmen P.; Broen, Jasper; Vonk, Madelon C.; Carreira, Patricia; Teresa Camps, Maria; Garcia-Portales, Rosa; Delgado-Frias, Esmeralda; Gallego, Maria; Espinosa, Gerard; Beretta, Lorenzo; Airo, Paolo; Lunardi, Claudio; Riemekasten, Gabriela; Witte, Torsten; Krieg, Thomas; Kreuter, Alexander; Distler, Joerg H. W.; Hunzelmann, Nicolas; Koeleman, Bobby P.; Voskuyl, Alexandre E.; Schuerwegh, Annemie J.; Angel Gonzalez-Gay, Miguel; Radstake, Timothy R. D. J.; Martin, Javier Spanish Scleroderma Grp. Arthritis Research & Therapy. 2012;  14 (3): – . DOI: 10.1186/ar3890.

 

– Mitochondrial Dysfunction Increases Inflammatory Responsiveness to Cytokines in Normal Human Chondrocytes. Vaamonde-Garcia, Carlos; Riveiro-Naveira, Romina R.; Valcarcel-Ares, Marta N.; Hermida-Carballo, Laura; Blanco, Francisco J.; Lopez-Armada, Maria J. Arthritis And Rheumatism. 2012; 64 (9): 2927- 2936. DOI: 10.1002/art.34508.

 

– Tofacitinib or Adalimumab versus Placebo in Rheumatoid Arthritis. van Vollenhoven, Ronald F.; Fleischmann, Roy; Cohen, Stanley; Lee, Eun Bong; Garcia Meijide, Juan A.; Wagner, Sylke; Forejtova, Sarka; Zwillich, Samuel H.; Gruben, David; Koncz, Tamas; Wallenstein, Gene V.; Krishnaswami, Sriram; Bradley, John D.; Wilkinson, Bethanie ORAL Standard Investigators. New England Journal Of Medicine. 2012; 367 (6): 508- 519. DOI: 10.1056/NEJMoa1112072.